Abnormal inhibition-excitation imbalance in migraine

BN Nguyen; AM McKendrick; AJ Vingrys

Journal article

Abnormal inhibition-excitation imbalance in migraine

BN Nguyen, AM McKendrick, AJ Vingrys

Cephalalgia | Published : 2016

DOI: 10.1177/0333102415576725

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Abstract

Background People with migraine show increased surround suppression of perceived contrast, a perceptual analogue of centre-surround antagonistic interactions in visual cortex. A proposed mechanism is that cortical 'hyperexcitability' or 'hyperresponsivity', a prominent theory in the migraine literature, drives abnormal excitatory-inhibitory balance to give increased local inhibition. The purpose of this cross-sectional study was to determine whether cortical hyperresponsivity and excitatory-inhibitory imbalance manifests in the visual cortical response of migraine sufferers. Methods Interictal steady-state visual evoked potentials (VEPs) in response to 0 to 97% contrast were recorded in 30 m..

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University of Melbourne Researchers

Bao Nguyen Author

Allison McKendrick Author

Algis Vingrys Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council grant (number 509208) to A.M.M. and Australian Research Council grant (number FT0990930) to A.M.M. B.N.N. was supported by the Elizabeth and Vernon Puzey Postgraduate Scholarship from the Faculty of Science at the University of Melbourne.